Please use this identifier to cite or link to this item: https://doi.org/10.1093/cvr/cvs095
Title: RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
Authors: Poon, K.L.
Tan, K.T.
Wei, Y.Y.
Ng, C.P.
Colman, A.
Korzh, V. 
Xu, X.Q.
Keywords: Cardiomyopathy
RNA-binding protein
Sarcomere
Stem cells
Zebrafish
Issue Date: 1-Jun-2012
Citation: Poon, K.L., Tan, K.T., Wei, Y.Y., Ng, C.P., Colman, A., Korzh, V., Xu, X.Q. (2012-06-01). RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility. Cardiovascular Research 94 (3) : 418-427. ScholarBank@NUS Repository. https://doi.org/10.1093/cvr/cvs095
Abstract: Aims The factors responsible for cardiomyopathy are not fully understood. Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart development. Methods and resultsThe expression of Rbm24 was detected in mouse cardiomyocytes and embryonic myocardium of zebrafish at the RNA and protein level. The Rbm24 loss-of-function showed that Rbm24 deficiency resulted in a reduction in sarcomeric proteins, Z-disc abnormality, and diminished heart contractility, resulting in the absence of circulation in zebrafish embryos. Gene expression profiling revealed down-regulation of multiple pathways associated with sarcomere assembly and vasculature development in Rbm24 deficiency. Conclusion We identified a novel role of the tissue-specific RNA-binding protein (RBP) Rbm24 involving in the regulation of cardiac gene expression, sarcomeric assembly, and cardiac contractility. This study uncovers a potential novel pathway to cardiomyopathy through down-regulation of the RBP Rbm24. © 2012 The Author.
Source Title: Cardiovascular Research
URI: http://scholarbank.nus.edu.sg/handle/10635/101607
ISSN: 00086363
DOI: 10.1093/cvr/cvs095
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

33
checked on Jun 15, 2018

WEB OF SCIENCETM
Citations

31
checked on May 23, 2018

Page view(s)

39
checked on May 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.