Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1439-0426.2012.01983.x
Title: Osterix: NlGFP transgenic medaka identify regulatory roles for retinoic acid signaling during osteoblast differentiation in vivo
Authors: Renn, J. 
Winkler, C. 
Issue Date: Jun-2012
Citation: Renn, J., Winkler, C. (2012-06). Osterix: NlGFP transgenic medaka identify regulatory roles for retinoic acid signaling during osteoblast differentiation in vivo. Journal of Applied Ichthyology 28 (3) : 360-363. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1439-0426.2012.01983.x
Abstract: Recent findings suggest that retinoic acid (RA) plays an important role for osteoblast differentiation and function in mammals as well as teleost fish. In this study, we show that treatment of medaka embryos with retinoic acid leads to an over-ossification in the cranial and axial skeleton, while inhibition of endogenous RA synthesis reduces bone ossification. Using transgenic medaka carrying the osterix (osx) promoter to drive osteoblast-specific reporter gene expression, we show that an increase of retinoic acid levels leads to mis-localization of osx expressing osteoblasts and condensed transgenic expression in the axial skeleton, while inhibition of RA synthesis reduces the number of osx positive cells and consequently bone ossification. Our in vivo data suggest that distinct RA levels are necessary to control differentiation of early osteoblasts and promote the mineralizing activity of mature osteoblasts. © 2012 Blackwell Verlag, Berlin.
Source Title: Journal of Applied Ichthyology
URI: http://scholarbank.nus.edu.sg/handle/10635/101334
ISSN: 01758659
DOI: 10.1111/j.1439-0426.2012.01983.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

7
checked on Jun 19, 2018

WEB OF SCIENCETM
Citations

6
checked on Jun 12, 2018

Page view(s)

44
checked on Jun 8, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.