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|Title:||Neurogranin expression in stably transfected N2A cell line affects cytosolic calcium level by nitric oxide stimulation|
Cytosolic-free calcium concentration
|Citation:||Yang, H.M., Lee, P.H.-H., Lim, T.M., Sheu, F.-S. (2004-10-22). Neurogranin expression in stably transfected N2A cell line affects cytosolic calcium level by nitric oxide stimulation. Molecular Brain Research 129 (1-2) : 171-178. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molbrainres.2004.06.039|
|Abstract:||To test a cellular effect of rodent neurogranin (Ng) oxidation as compared to Ng phosphorylation, we develop a cell model capable of stable expression of Ng using the Tet-On system, and determine whether Ng oxidation regulates intracellular calcium level. Our results show that Ng oxidation by nitric oxide donor induces an increase of [Ca 2+] i in Ng-expressed cells as compared to the control cells without expressing Ng. These results suggest that Ng oxidation plays a significant role in intracellular Ca 2+ homeostasis, essential for the activated signaling networks in learning and memory. © 2004 Elsevier B.V. All rights reserved.|
|Source Title:||Molecular Brain Research|
|Appears in Collections:||Staff Publications|
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