Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.molbrainres.2004.06.039
Title: Neurogranin expression in stably transfected N2A cell line affects cytosolic calcium level by nitric oxide stimulation
Authors: Yang, H.M.
Lee, P.H.-H.
Lim, T.M. 
Sheu, F.-S. 
Keywords: Calmodulin-binding protein
Cytosolic-free calcium concentration
Neurogranin
Nitric oxide
Oxidation
Phosphorylation
Issue Date: 22-Oct-2004
Source: Yang, H.M., Lee, P.H.-H., Lim, T.M., Sheu, F.-S. (2004-10-22). Neurogranin expression in stably transfected N2A cell line affects cytosolic calcium level by nitric oxide stimulation. Molecular Brain Research 129 (1-2) : 171-178. ScholarBank@NUS Repository. https://doi.org/10.1016/j.molbrainres.2004.06.039
Abstract: To test a cellular effect of rodent neurogranin (Ng) oxidation as compared to Ng phosphorylation, we develop a cell model capable of stable expression of Ng using the Tet-On system, and determine whether Ng oxidation regulates intracellular calcium level. Our results show that Ng oxidation by nitric oxide donor induces an increase of [Ca 2+] i in Ng-expressed cells as compared to the control cells without expressing Ng. These results suggest that Ng oxidation plays a significant role in intracellular Ca 2+ homeostasis, essential for the activated signaling networks in learning and memory. © 2004 Elsevier B.V. All rights reserved.
Source Title: Molecular Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/101193
ISSN: 0169328X
DOI: 10.1016/j.molbrainres.2004.06.039
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