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https://doi.org/10.1002/dvdy.10127
DC Field | Value | |
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dc.title | Morphologic transformation of the thymus in developing zebrafish | |
dc.contributor.author | Lam, S.H. | |
dc.contributor.author | Chua, H.L. | |
dc.contributor.author | Gong, Z. | |
dc.contributor.author | Wen, Z. | |
dc.contributor.author | Lam, T.J. | |
dc.contributor.author | Sin, Y.M. | |
dc.date.accessioned | 2014-10-27T08:34:09Z | |
dc.date.available | 2014-10-27T08:34:09Z | |
dc.date.issued | 2002-09 | |
dc.identifier.citation | Lam, S.H., Chua, H.L., Gong, Z., Wen, Z., Lam, T.J., Sin, Y.M. (2002-09). Morphologic transformation of the thymus in developing zebrafish. Developmental Dynamics 225 (1) : 87-94. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.10127 | |
dc.identifier.issn | 10588388 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/101157 | |
dc.description.abstract | The morphologic transformation of the developing zebrafish thymus from 1 week postfertilization (wpf) to 15 wpf is described. The thymus overall morphology changed from a small pouch-like shape at 1 wpf to a conical shape between 2 and 3 wpf before acquiring a more complex shape from 4 wpf onward. Rapid growth rate along the lateral axis at the region near the pharyngeal epithelium occurred between 1 and 2 wpf, whereas rapid growth rate along the dorsal-ventral axis occurred between 3 and 6 wpf. Expansion of thymocyte population beginning from 1 wpf became more evident by 2 to 3 wpf, as indicated by the apparent increase of different sizes of lymphocytes, recombination activating gene-1 (rag-1), and T-cell antigen receptor alpha chain constant region (TCRAC) -positive cells. Tissue section in situ hybridization (ISH) analysis with rag-1 probe reveals that cortex-medullary regionalization has begun between 1 and 2 wpf as rag-1 expression clearly demarcated the cortex, whereas the medulla was rag-1 negative. The presence of TCRAC-positive cells in the medulla by 2-3 wpf, suggests that the thymic selection processes had begun. The zebrafish thymus is morphologically mature by 3 wpf. Early signs of thymic involution were observed in zebrafish aged 15 wpf. © 2002 Wiley-Liss, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/dvdy.10127 | |
dc.source | Scopus | |
dc.subject | Cortex-medullary regionalization | |
dc.subject | Morphologic transformation | |
dc.subject | Recombination activating gene-1 | |
dc.subject | T-cell receptor | |
dc.subject | Thymus | |
dc.subject | Zebrafish development | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1002/dvdy.10127 | |
dc.description.sourcetitle | Developmental Dynamics | |
dc.description.volume | 225 | |
dc.description.issue | 1 | |
dc.description.page | 87-94 | |
dc.description.coden | DEDYE | |
dc.identifier.isiut | 000177806900010 | |
Appears in Collections: | Staff Publications |
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