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|Title:||Molecular moulds with multiple missions: Functional sites in three-finger toxins|
|Citation:||Kini, R.M. (2002). Molecular moulds with multiple missions: Functional sites in three-finger toxins. Clinical and Experimental Pharmacology and Physiology 29 (9) : 815-822. ScholarBank@NUS Repository. https://doi.org/10.1046/j.1440-1681.2002.03725.x|
|Abstract:||1. Snake venoms are complex mixtures of pharmacologically active peptides and proteins. 2. These protein toxins belong to a small number of superfamilies of proteins. The present review describes structure-function relationships of three-finger toxins. 3. All toxins share a common structure of three β-stranded loops extending from a central core. However, they bind to different receptors/acceptors and exhibit a wide variety of biological effects. 4. Thus, the structure-function relationships of this group of toxins are complicated and challenging. 5. Studies have shown that the functional sites in these 'sibling' toxins are located on various segments of the molecular surface.|
|Source Title:||Clinical and Experimental Pharmacology and Physiology|
|Appears in Collections:||Staff Publications|
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