Please use this identifier to cite or link to this item: https://doi.org/10.1002/dvdy.21384
Title: Midkine-b regulates cell specification at the neural plate border in zebrafish
Authors: Liedtke, D.
Winkler, C. 
Keywords: Heparin-binding growth factors
Midkine
Neural crest
Pleiotrophin
Sensory neurons
Zebrafish
Issue Date: Jan-2008
Source: Liedtke, D., Winkler, C. (2008-01). Midkine-b regulates cell specification at the neural plate border in zebrafish. Developmental Dynamics 237 (1) : 62-74. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.21384
Abstract: Midkines compose a family of secreted, heparin-binding growth factors with neurotrophic activity in vitro, but largely unknown functions in mammals in vivo. Here we show that one member of this family, Midkine-b (Mdkb), is responsible for establishment of the neural plate border in zebrafish. We propose that MdkB acts downstream of several signaling factors, most notably retinoic acid, implicated in neural crest cell (ncc) induction and refines a zone of competence for ncc and Rohon-Beard (RB) sensory neuron formation. Overexpression of Mdkb expands the cell numbers of various ncc precursor subtypes and results in a significant increase in the number of RB neurons at the neural plate border. On the other hand, Morpholino-mediated knockdown of Mdkb leads to a dramatic reduction of ncc and a loss of sensory neurons. Our results imply that Mdkb is required for the earliest steps of cell specification at the neural plate border in zebrafish. © 2007 Wiley-Liss, Inc.
Source Title: Developmental Dynamics
URI: http://scholarbank.nus.edu.sg/handle/10635/101097
ISSN: 10588388
DOI: 10.1002/dvdy.21384
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