Please use this identifier to cite or link to this item: https://doi.org/10.1002/dvdy.21477
Title: Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish
Authors: Chen, L.-J.
Hsu, C.-C.
Hong, J.-R.
Jou, L.-K.
Tseng, H.-C.
Wu, J.-L.
Liou, Y.-C. 
Her, G.M.
Keywords: Agenesis, atrophy
Contraction
GFP
Hepatogenesis
Hypoplasia
Liver degeneration
Mdm2
p53
Issue Date: Apr-2008
Source: Chen, L.-J., Hsu, C.-C., Hong, J.-R., Jou, L.-K., Tseng, H.-C., Wu, J.-L., Liou, Y.-C., Her, G.M. (2008-04). Liver-specific expression of p53-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish. Developmental Dynamics 237 (4) : 1070-1081. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.21477
Abstract: Tumorigenesis requires inactivation of the p53 tumor suppressor pathway, likely involving the negative regulator Mdm2 protein. To analyze the possible roles of Mdm2 in oncogenesis and other functions during zebrafish hepatogenesis, we generated transgenic zebrafish by liver-specific Mdm2 over-expression utilizing a fusion between genes encoding GFP and mdm2, GFP
Source Title: Developmental Dynamics
URI: http://scholarbank.nus.edu.sg/handle/10635/101025
ISSN: 10588388
DOI: 10.1002/dvdy.21477
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