Please use this identifier to cite or link to this item:
|Title:||Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity|
Le Du, M.H.
|Citation:||Pawlak, J., Mackessy, S.P., Sixberry, N.M., Stura, E.A., Le Du, M.H., Méenez, R., Foo, C.S., Ménez, A., Nirthanan, S., Kini, R.M. (2009-02). Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity. FASEB Journal 23 (2) : 534-545. ScholarBank@NUS Repository. https://doi.org/10.1096/fj.08-113555|
|Abstract:||A novel heterodimeric three-finger neurotoxin, irditoxin, was isolated from venom of the brown treesnake Boiga irregularis (Colubridae). Irditoxin subunit amino acid sequences were determined by Edman degradation and cDNA sequencing. The crystal structure revealed two subunits with a three-finger protein fold, typical for "nonconventional" toxins such as denmotoxin, bucandin, and candoxin. This is the first colubrid three- finger toxin dimer, covalently connected via an interchain disulfide bond. Irditoxin showed taxon-specific lethality toward birds and lizards and was nontoxic toward mice. It produced a potent neuromuscular blockade at the avian neuromuscular junction (IC 50=10 nM), comparable to α-bungarotoxin, but was three orders of magnitude less effective at the mammalian neuromuscular junction. Co- valently linked heterodimeric three-finger toxins found in colubrid venoms constitute a new class of venom pep- tides, which may be a useful source of new neurobiology probes and therapeutic leads. © FASEB.|
|Source Title:||FASEB Journal|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 14, 2018
WEB OF SCIENCETM
checked on May 7, 2018
checked on May 18, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.