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|Title:||Investigating highly replicated asthma genes as candidate genes for allergic rhinitis|
De Yun, W.
|Citation:||Andiappan, A.K., Nilsson, D., Halldén, C., De Yun, W., Säll, T., Cardell, L.O., Tim, C.F. (2013-05-10). Investigating highly replicated asthma genes as candidate genes for allergic rhinitis. BMC Medical Genetics 14 (1) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2350-14-51|
|Abstract:||Background: Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion of individuals with asthma also present symptoms of AR, and patients with AR have a 5-6 fold increased risk of developing asthma. Thus, the relevance of asthma candidate genes as predisposing factors for AR is worth investigating. The present study was designed to investigate if SNPs in highly replicated asthma genes are associated with the occurrence of AR.Methods: A total of 192 SNPs from 21 asthma candidate genes reported to be associated with asthma in 6 or more unrelated studies were genotyped in a Swedish population with 246 AR patients and 431 controls. Genotypes for 429 SNPs from the same set of genes were also extracted from a Singapore Chinese genome-wide dataset which consisted of 456 AR cases and 486 controls. All SNPs were subsequently analyzed for association with AR and their influence on allergic sensitization to common allergens.Results: A limited number of potential associations were observed and the overall pattern of P-values corresponds well to the expectations in the absence of an effect. However, in the tests of allele effects in the Chinese population the number of significant P-values exceeds the expectations. The strongest signals were found for SNPs in NPSR1 and CTLA4. In these genes, a total of nine SNPs showed P-values|
|Source Title:||BMC Medical Genetics|
|Appears in Collections:||Staff Publications|
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