Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/100956
Title: Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor
Authors: Tan, E.
Low, K.W. 
Wong, W.S.F.
Leung, K.Y. 
Keywords: Aeromonas hydrophila
Fish epithelial cells
Tyrosine kinase
Issue Date: Feb-1998
Source: Tan, E.,Low, K.W.,Wong, W.S.F.,Leung, K.Y. (1998-02). Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor. Microbiology 144 (2) : 299-307. ScholarBank@NUS Repository.
Abstract: Aeromonas hydrophila is a Gram-negative bacterium that is pathogenic in fish, causing motile aeromonad septicaemia. It can enter (invade) fish cells, and survive as an intracellular parasite. The host-pathogen interaction and signal transduction pathway were studied by screening signal transduction inhibitors using carp epithelial cells and a virulent strain of the bacterium, PPD134/91. Genistein, a tyrosine kinase inhibitor, postponed internalization of A. hydrophila into host cells, suggesting that tyrosine phosphorylation plays a role in internalization. In contrast, staurosporine, a protein kinase C inhibitor, and sodium orthovanadate, a protein tyrosine phosphatase inhibitor, accelerated internalization of PPD134/91. Other virulent strains of A. hydrophila were also examined and it is likely that all strains, irrespective of serogroup, use the same signalling pathway to facilitate bacterial uptake.
Source Title: Microbiology
URI: http://scholarbank.nus.edu.sg/handle/10635/100956
ISSN: 13500872
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

32
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.