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Title: Induction of transient ion channel-like pores in a cancer cell by antibiotic peptide
Authors: Ye, J.-S. 
Zheng, X.-J.
Leung, K.W.
Chen, H.M.
Sheu, F.-S. 
Keywords: Antibiotic peptides
Cancer cell
Cecropin B
Patch clamp technique
Pore formation
Issue Date: Aug-2004
Source: Ye, J.-S., Zheng, X.-J., Leung, K.W., Chen, H.M., Sheu, F.-S. (2004-08). Induction of transient ion channel-like pores in a cancer cell by antibiotic peptide. Journal of Biochemistry 136 (2) : 255-259. ScholarBank@NUS Repository.
Abstract: The anticancer activity of anti-bacterial cecropins makes them potentially useful as peptide anti-cancer drugs. We used the cell-attached patch to study the effect of cecropin B (CB; having one hydrophobic and one amphipathic α-helix) and its derivative, cecropin B3 (CE3; having two hydrophobic α-helices) on the membrane of Ags cancer cells. Application of 10-60 μM CB onto the membrane of the cancer cell produces short outward currents. Comparative study with CB3, which induces no outward currents, shows that the amphipathic group of CB is necessary for the pore formation. The results provide a rationale to study the cell-killing activity of antimicrobial peptides at the single cancer cell level.
Source Title: Journal of Biochemistry
ISSN: 0021924X
DOI: jb/mvh114
Appears in Collections:Staff Publications

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