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Title: Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma
Authors: Wang, J.-Y.
Xu, X.-Y.
Jia, J.-H. 
Wu, C.-H.
Ge, R.-W. 
Keywords: Endothelial cell
Enzyme-linked immunosorbent assay
Hepatocellular carcinoma
Tumor angiogenesis
Issue Date: 20-Mar-2010
Citation: Wang, J.-Y., Xu, X.-Y., Jia, J.-H., Wu, C.-H., Ge, R.-W. (2010-03-20). Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma. Chinese Medical Journal 123 (6) : 730-733. ScholarBank@NUS Repository.
Abstract: Background: Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. In order to investigate the molecular biologic mechanism of HCC's development, we studied the expressions of SE-1, CD105 and CD31 in tumor endothelial cells (TECs) of HCC and in the serum of rats. Methods: We analyzed the expressions of SE-1, CD31 and CD105 in rat HCC tumor tissues using immunohistochemistry (IHC). Twenty HCC bearing rats and eighteen normal rats were examined for the expressions of SE-1, CD31 and CD105 antigens in serum by enzyme-linked immunosorbent assay (ELISA). Results: SE-1, CD31 and CD105 antigens were detected both in HCC tissue and in normal liver tissue with higher expressions of CD31 and CD105 in HCC while the SE-1 antigen expression was higher in normal liver. Similarly, serum CD31 and CD105 in rats with HCC were significantly increased compared with normal rats (t=2.8628, P=0.0086; t=4.4922, P
Source Title: Chinese Medical Journal
ISSN: 03666999
DOI: 10.3760/cma.j.issn.0366-6999.2010.06.017
Appears in Collections:Staff Publications

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