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https://doi.org/10.1002/btpr.34
Title: | Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus | Authors: | Praseuth, A.P. Wang, C.C.C. Watanabe, K. Hotta, K. Oguri, H. Oikawa, H. |
Keywords: | Echinomycin Nonribosomal peptide synthetase Quinomycin-type antibiotics Streptomyces triostinicus Triostin A |
Issue Date: | Nov-2008 | Citation: | Praseuth, A.P., Wang, C.C.C., Watanabe, K., Hotta, K., Oguri, H., Oikawa, H. (2008-11). Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress 24 (6) : 1226-1231. ScholarBank@NUS Repository. https://doi.org/10.1002/btpr.34 | Abstract: | Streptomyces triostinicus produces triostin A, an antitumor antibiotic, as its major secondary metabolite. Surprisingly, this strain also produced a trace amount of echinomycin. We sequenced the entire triostin A biosynthetic gene cluster from S. triostinicus, and found that this 36 kilobase-long gene cluster contained an ORF homologous to ecm18 that encodes a thioacetal-forming enzyme responsible for the triostin A-to-echinomycin bioconversion. These findings indicate that, unlike previously thought, S. triostinicus is capable of producing not only triostin A but also echinomycin. Our observation suggests potential value in careful reanalysis for metabolites from previously characterized natural product producers with the current technologies. © 2008 American Institute of Chemical Engineers. | Source Title: | Biotechnology Progress | URI: | http://scholarbank.nus.edu.sg/handle/10635/100311 | ISSN: | 87567938 | DOI: | 10.1002/btpr.34 |
Appears in Collections: | Staff Publications |
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