Please use this identifier to cite or link to this item: https://doi.org/10.1002/btpr.34
Title: Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus
Authors: Praseuth, A.P.
Wang, C.C.C.
Watanabe, K.
Hotta, K. 
Oguri, H.
Oikawa, H.
Keywords: Echinomycin
Nonribosomal peptide synthetase
Quinomycin-type antibiotics
Streptomyces triostinicus
Triostin A
Issue Date: Nov-2008
Citation: Praseuth, A.P., Wang, C.C.C., Watanabe, K., Hotta, K., Oguri, H., Oikawa, H. (2008-11). Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress 24 (6) : 1226-1231. ScholarBank@NUS Repository. https://doi.org/10.1002/btpr.34
Abstract: Streptomyces triostinicus produces triostin A, an antitumor antibiotic, as its major secondary metabolite. Surprisingly, this strain also produced a trace amount of echinomycin. We sequenced the entire triostin A biosynthetic gene cluster from S. triostinicus, and found that this 36 kilobase-long gene cluster contained an ORF homologous to ecm18 that encodes a thioacetal-forming enzyme responsible for the triostin A-to-echinomycin bioconversion. These findings indicate that, unlike previously thought, S. triostinicus is capable of producing not only triostin A but also echinomycin. Our observation suggests potential value in careful reanalysis for metabolites from previously characterized natural product producers with the current technologies. © 2008 American Institute of Chemical Engineers.
Source Title: Biotechnology Progress
URI: http://scholarbank.nus.edu.sg/handle/10635/100311
ISSN: 87567938
DOI: 10.1002/btpr.34
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