Please use this identifier to cite or link to this item:
|Title:||Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus|
Nonribosomal peptide synthetase
|Citation:||Praseuth, A.P., Wang, C.C.C., Watanabe, K., Hotta, K., Oguri, H., Oikawa, H. (2008-11). Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnology Progress 24 (6) : 1226-1231. ScholarBank@NUS Repository. https://doi.org/10.1002/btpr.34|
|Abstract:||Streptomyces triostinicus produces triostin A, an antitumor antibiotic, as its major secondary metabolite. Surprisingly, this strain also produced a trace amount of echinomycin. We sequenced the entire triostin A biosynthetic gene cluster from S. triostinicus, and found that this 36 kilobase-long gene cluster contained an ORF homologous to ecm18 that encodes a thioacetal-forming enzyme responsible for the triostin A-to-echinomycin bioconversion. These findings indicate that, unlike previously thought, S. triostinicus is capable of producing not only triostin A but also echinomycin. Our observation suggests potential value in careful reanalysis for metabolites from previously characterized natural product producers with the current technologies. © 2008 American Institute of Chemical Engineers.|
|Source Title:||Biotechnology Progress|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 15, 2019
WEB OF SCIENCETM
checked on Feb 6, 2019
checked on Jan 18, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.