Please use this identifier to cite or link to this item: https://doi.org/10.1089/zeb.2009.0608
Title: Comparative transcriptome analyses revealed conserved biological and transcription factor target modules between the zebrafish and human tumors
Authors: Ung, C.Y. 
Lam, S.H. 
Gong, Z. 
Issue Date: 1-Dec-2009
Citation: Ung, C.Y., Lam, S.H., Gong, Z. (2009-12-01). Comparative transcriptome analyses revealed conserved biological and transcription factor target modules between the zebrafish and human tumors. Zebrafish 6 (4) : 425-431. ScholarBank@NUS Repository. https://doi.org/10.1089/zeb.2009.0608
Abstract: In an effort of validating the zebrafish model for studies of human tumors, our previous transcriptome analyses revealed striking molecular similarities between zebrafish and human liver neoplasia. However, as biological processes function at modular levels such as pathways and cascades, it is also important to capture conservation at the modular levels and in regulatory program(s) controlling these modules. In this study, we performed comparative transcriptome analyses with two modules, biological modules and transcription factor target modules, using gene set enrichment analysis against carcinogen-induced liver tumors in zebrafish with four tissue types of human tumors. We observed conservation of enriched modules that are associated to tumorigenesis such as cell cycle, metastasis, and hypoxia in these tumors. More importantly, we identified conserved regulatory programs linking these cancer-related modules with transcription factors and oncogenes such as Myc, E2F, STAT, and YY1. Taken together, our analyses revealed that carcinogen-induced liver tumors in zebrafish capture cancerous hallmarks observed in human tumors not only for cancer-related biological modules but also at transcriptional program, further implicating conserved tumorigenesis mechanism in both zebrafish and human. © Mary Ann Liebert, Inc.
Source Title: Zebrafish
URI: http://scholarbank.nus.edu.sg/handle/10635/100307
ISSN: 15458547
DOI: 10.1089/zeb.2009.0608
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

10
checked on Aug 22, 2018

WEB OF SCIENCETM
Citations

10
checked on Aug 22, 2018

Page view(s)

30
checked on Aug 10, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.