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Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3835(01)00707-8
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dc.titleCancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants
dc.contributor.authorItoigawa, M.
dc.contributor.authorIto, C.
dc.contributor.authorTan, H.T.-W.
dc.contributor.authorOkuda, M.
dc.contributor.authorTokuda, H.
dc.contributor.authorNishino, H.
dc.contributor.authorFurukawa, H.
dc.date.accessioned2014-10-27T08:23:15Z
dc.date.available2014-10-27T08:23:15Z
dc.date.issued2001-12-28
dc.identifier.citationItoigawa, M., Ito, C., Tan, H.T.-W., Okuda, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-12-28). Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants. Cancer Letters 174 (2) : 135-139. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(01)00707-8
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100209
dc.description.abstractAs a part of screening studies for cancer chemopreventive agents (anti-tumor promoters), six natural and four synthetic naphthoquinones and five of their analogs were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxicity. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-ring, displayed the most potent activity. Furthermore, avicenol-A (9) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these 1,4-naphthoquinones and their analogs might be valuable as potent cancer chemopreventive agents. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3835(01)00707-8
dc.sourceScopus
dc.subjectAnti-tumor-promoting effect
dc.subjectAvicennia plants
dc.subjectCancer chemopreventive agents
dc.subjectEpstein-Barr virus activation
dc.subjectNaphthoquinones
dc.subjectTwo-stage mouse skin carcinogenesis
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/S0304-3835(01)00707-8
dc.description.sourcetitleCancer Letters
dc.description.volume174
dc.description.issue2
dc.description.page135-139
dc.description.codenCALED
dc.identifier.isiut000172255500004
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