Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0042642
Title: Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3
Authors: Funston, G.
Goh, W.
Wei, S.J.
Tng, Q.S.
Brown, C.
Jiah Tong, L.
Verma, C. 
Lane, D.
Ghadessy, F.
Issue Date: 13-Aug-2012
Citation: Funston, G., Goh, W., Wei, S.J., Tng, Q.S., Brown, C., Jiah Tong, L., Verma, C., Lane, D., Ghadessy, F. (2012-08-13). Binding of translationally controlled tumour protein to the N-terminal domain of HDM2 is inhibited by Nutlin-3. PLoS ONE 7 (8) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0042642
Abstract: Translationally Controlled Tumour Protein (TCTP), a highly conserved protein present in all eukaryotic organisms, has a number of intracellular and extracellular functions including an anti-apoptotic role. TCTP was recently shown to interact with both p53 and HDM2, inhibiting auto-ubiquitination of the latter and thereby promoting p53 degradation. In this study, we further investigated the interaction between TCTP and HDM2, mapping the reciprocal binding sites of TCTP and HDM2. TCTP primarily interacts with the N-terminal, p53-binding region of HDM2 through its highly basic domain 2. Furthermore, we discovered that Nutlin-3, a small molecule known to promote apoptosis and cell cycle arrest by blocking binding between HDM2 and p53, has a similar inhibitory effect on the interaction of HDM2 and TCTP. This result may provide an additional explanation of how Nutlin-derived compounds currently in clinical trials function to promote apoptosis in cancer cells. © 2012 Funston et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/100165
ISSN: 19326203
DOI: 10.1371/journal.pone.0042642
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

11
checked on Nov 13, 2018

WEB OF SCIENCETM
Citations

7
checked on Oct 30, 2018

Page view(s)

42
checked on Oct 26, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.