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| Title: | Anticoagulant venom and mammalian secreted phospholipases A2: Protein- versus phospholipid-dependent mechanism of action | Authors: | Mounier, C.M. Bon, C. Kini, R.M. |
Keywords: | Anticoagulant Factor Va Factor Xa Mammalian Secreted phospholipase A2 Snake venom |
Issue Date: | 2001 | Citation: | Mounier, C.M.,Bon, C.,Kini, R.M. (2001). Anticoagulant venom and mammalian secreted phospholipases A2: Protein- versus phospholipid-dependent mechanism of action. Haemostasis 31 (3-6) : 279-287. ScholarBank@NUS Repository. | Abstract: | Some venom and mammalian-secreted phospholipases A2 (sPLA2) have been described to exert an anticoagulant effect. This review will discuss and compare phospholipid-dependent versus protein-dependent mechanisms of action of these sPLA2 on the coagulation cascade. The importance of venom proteins, and of the study of their pharmacological effects, to explore the physiological functions of homologous mammalian proteins is also pointed out. Copyright © 2002 S. Karger AG, Basel. | Source Title: | Haemostasis | URI: | http://scholarbank.nus.edu.sg/handle/10635/100095 | ISSN: | 03010147 |
| Appears in Collections: | Staff Publications |
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