Please use this identifier to cite or link to this item: https://doi.org/10.1006/excr.2002.5597
Title: Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice
Authors: Shim, W.S.N.
Teh, M.
Bapna, A.
Kim, I.
Koh, G.-Y.
Mack, P.O.P.
Ge, R. 
Keywords: Angiopoietin 1
Tumor angiogenesis
Vessel plasticity
Issue Date: 2002
Citation: Shim, W.S.N., Teh, M., Bapna, A., Kim, I., Koh, G.-Y., Mack, P.O.P., Ge, R. (2002). Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Experimental Cell Research 279 (2) : 299-309. ScholarBank@NUS Repository. https://doi.org/10.1006/excr.2002.5597
Abstract: Angiopoietins have been increasingly implicated to play important roles in blood vessel formation, remodeling, maturation, and maintenance. However, their roles in tumor angiogenesis and hence tumor growth and metastasis still remain uncertain. In this work, angiopoietin 1 expression was amplified in human cervical cancer HeLa cells by stable transfection or recombinant human adenovirus-mediated gene transfer. We show that increased angiopoietin 1 expression promoted in vivo growth of human cervical cancers in mice by promoting tumor angiogenesis and inhibiting tumor cell apoptosis. Furthermore, we also show for the first time that overexpression of angiopoietin 1 also leads to increased tumor vessel plasticity with a large number of vessels lacking periendothelial supporting cells. These results indicate that angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. © 2002 Elsevier Science (USA).
Source Title: Experimental Cell Research
URI: http://scholarbank.nus.edu.sg/handle/10635/100086
ISSN: 00144827
DOI: 10.1006/excr.2002.5597
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